Ghrelin and leptin: Two hormones that stimulate and suppress Appetite
Saturday, February 1, 2020
Before supermarkets and convenience stores, humans developed an amazing evolutionary survival tool. Ghrelin and leptin, two hormones that stimulate and suppress appetite respectively. Leptin is released from adipose cells. Long ago when humans had to hunt for food to survive, low leptin stocks were associated with hunger/starvation, weight loss or poor energy stores. This metabolic state would stimulate appetite and hunger and the desire to hunt, so to survive. Today, studies have found leptin resistance/insensitivity is seen in obesity much the same way that insulin resistance is seen in type II diabetes. In obesity, chronically elevated leptin hormone levels / leptin insensitivity does not satiate the appetite any more. The elevated leptin causes poor sleep efficiency with more nocturnal awakenings, suppresses the brains ability to support proper breathing while asleep and makes the airway more collapsible. This can lead to a host of health problems including OSA, hypertension, both pulmonary inflammation and systemic inflammation. It’s suggested that Leptin insensitivity may attenuate the brains ability to control respiratory drive and respond to rising carbon dioxide due to nocturnal hypoventilation. #osa #metabolicsyndrome #obesity #leptinresistance #longevity
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Wednesday, November 1, 2023
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Wednesday, February 21, 2024